Can You Take DHM Every Day? What We Know About Daily Use

Daily DHM hasn't been studied in healthy people: the longest human trial gave 300 mg a day, combined with vitamins, for 12 months to people with fatty liver disease, so ask a clinician before taking it every day. Can you take DHM every day at higher doses? Nobody knows. And if you find yourself wanting something after drinking most days, that's a reason to look at the drinking itself.

Key takeaways

  • Three randomized trials gave DHM daily: 970 mg for 1 month (type 2 diabetes), 300 or 600 mg for 3 months (fatty liver disease), and 300 mg with vitamins for 12 months (fatty liver disease).1, 2, 3
  • None of those trials involved alcohol or healthy adults, and NIH's LiverTox notes that DHM has had few prospective safety trials.4
  • In test-tube studies DHM inhibited CYP3A4, CYP2D6 and CYP2E1, a concern for anyone taking it regularly alongside medicines; it hasn't been tested in people.5
  • One serving of After Party by Fuller Health (3,250 mg of DHM) is about 3.4 times the highest daily dose in published human studies, and daily use at that dose hasn't been studied.1

What does daily DHM use look like?

Some people take a DHM supplement now and then; others take it on a schedule. The research says little about either pattern in people who drink. The only daily-use data come from trials in people with fatty liver disease or diabetes, at 300 to 970 mg a day.2, 1, 3 Labels differ in how often they say to take a product, so check yours.

Can you take DHM every day? What human studies found

Three small trials gave DHM every day for one to 12 months, all in people with a disease, and reported no major safety problems.

Human trials of daily DHM
Trial Who Daily DHM How long What was reported
Ran et al. 20191 80 adults with type 2 diabetes 970 mg, in vine tea 1 month Lower fasting glucose and some kidney markers than DHM-free vine tea.
Chen et al. 20152 60 adults with fatty liver disease 300 or 600 mg 3 months Lower liver enzymes, glucose and LDL cholesterol than placebo; no adverse events, per LiverTox.4
Michailidou et al. 20263 55 adults with fatty liver disease 300 mg, plus vitamins C and E and choline 12 months Liver enzymes normalized more often (35% vs. 5%).

These are lab-marker results in people with a disease. They don't show that daily DHM is safe or useful for healthy people who drink, and none tested amounts near some of today's products.

Why is long-term DHM safety unknown?

Because the long-term studies haven't been done.

  • LiverTox notes DHM "has not been subjected to many prospective trials of safety."4
  • The longest trial ran 12 months, at 300 mg a day, mixed with other ingredients.3
  • We found no published 90-day animal toxicity study of purified DHM.
  • No human absorption study has been published, so no one knows whether DHM builds up with daily use.6

After Party's 3,250 mg serving is higher than the doses used in published human DHM studies. Those studies gave up to about 970 mg a day, to people with fatty liver disease or type 2 diabetes, not to people who drink.1, 2, 3 Safety at 3,250 mg hasn't been studied.

Does daily DHM affect medications?

It might, and nobody has checked in people. In test-tube studies with human liver enzymes, DHM inhibited CYP3A4, CYP2D6 and CYP2E1, enzymes that help clear many medications.5 That hasn't been tested in people, so ask a pharmacist or doctor first if you take prescription medicines. If you take a medicine every day, that's exactly when an interaction would matter. Sedatives and sleep medicines haven't been studied with DHM either.7 Don't use DHM if you're pregnant or breastfeeding. More in Is DHM safe?

Occasional vs. daily: what do label directions say?

Follow your product's label, including how often it says to take it, and don't go over it.

After Party, for example, is a single-ingredient DHM supplement: 650 mg of dihydromyricetin per capsule, 3,250 mg per 5-capsule serving, with nothing else but the cellulose capsule. (Fuller Health publishes this page and makes After Party.) The label says to take 3 capsules before bed and 2 capsules upon waking. There are no data on taking it every day, so if you're considering that, talk to a clinician first. See how to take After Party, the After Party facts page and DHM dosage and timing.

What if you're drinking most days?

Then the more useful question is about the drinking, not the supplement. No supplement offsets regular drinking.

The previous US guidelines (2020 to 2025) set limits of 2 drinks or fewer a day for men and 1 or fewer for women, on days people drink.8 Fatty liver develops in more than 90% of problem drinkers who have 4 to 5 drinks a day over decades, and stopping drinking is the core of treatment for alcohol-related liver disease.9 If you're reaching for help most mornings, raise it with a doctor. More in liver support after drinking and how to drink responsibly.

What we don't know yet about daily DHM

  • Whether daily DHM is safe beyond 12 months, or above about 1 gram a day.
  • Whether it builds up in the body with daily use.
  • Whether it interacts with everyday medicines in people.
  • Whether any effect changes with regular use.

We log new studies in our DHM research tracker.

Frequently asked questions

Is it OK to take DHM daily?

There are no long-term safety data in healthy people. Trials gave 300 to 970 mg a day for up to 12 months to people with fatty liver disease or diabetes, without major problems; higher doses and longer use haven't been studied.1, 3 Ask a clinician first, especially if you take medicines.

Can you build a tolerance to DHM?

No study has looked at tolerance to DHM in people. The 2012 rat study found that injected DHM reduced the rats' tolerance to alcohol, which is a different question.7

Does DHM help fatty liver?

It hasn't been shown to. Two small trials in people with fatty liver disease not caused by alcohol reported better liver enzymes, but neither proves DHM treats the condition.2, 3 Fatty liver needs a doctor's care; for alcohol-related fatty liver, stopping drinking is the core of treatment.9

Should I cycle DHM?

There's no evidence either way: cycling schedules aren't based on DHM research. Follow your label, and ask a clinician if you're considering regular use.

Sources

  1. Ran L, et al. Ampelopsis grossedentata supplementation effectively ameliorates the glycemic control in patients with type 2 diabetes mellitus. Eur J Clin Nutr. 2019;73(5):776-782. PubMed
  2. Chen S, et al. Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial. Pharmacol Res. 2015;99:74-81. PubMed
  3. Michailidou E, et al. Dietary supplement based on dihydromyricetin in metabolic dysfunction-associated steatotic liver disease: a double-blind, placebo-controlled, randomized clinical trial. Ann Gastroenterol. 2026;39(1):54-62. PubMed
  4. National Institute of Diabetes and Digestive and Kidney Diseases. LiverTox: Dihydromyricetin. NCBI Bookshelf. Last updated August 16, 2023. NCBI Bookshelf
  5. Liu L, et al. In vitro inhibitory effects of dihydromyricetin on human liver cytochrome P450 enzymes. Pharm Biol. 2017;55(1):1868-1874. PubMed
  6. University of Southern California. Phase I, Dose-Escalation Study of Dihydromyricetin (DHM) to Treat Alcohol-Associated Liver Disease (NCT05623501). ClinicalTrials.gov. Status unknown; no results posted as of October 9, 2026. ClinicalTrials.gov
  7. Shen Y, et al. Dihydromyricetin as a novel anti-alcohol intoxication medication. J Neurosci. 2012;32(1):390-401. PubMed
  8. U.S. Department of Agriculture; U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2020-2025. December 2020. PDF
  9. Osna NA, et al. Alcoholic Liver Disease: Pathogenesis and Current Management. Alcohol Res. 2017;38(2):147-161. PubMed
  10. U.S. Department of Agriculture; U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2025-2030. Released January 7, 2026. PDF
  11. National Institute on Alcohol Abuse and Alcoholism. Hangovers. Updated December 2025. NIAAA
  12. Substance Abuse and Mental Health Services Administration. SAMHSA's National Helpline. SAMHSA
  13. MedlinePlus, U.S. National Library of Medicine. Alcohol withdrawal. Reviewed January 1, 2025. MedlinePlus

Published by Fuller Health, which makes After Party. This article is general information, not medical advice: talk to a doctor or pharmacist about your own health, medicines and drinking. Last reviewed October 9, 2026. How we research and write.

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