DHM Dosage: How Much Dihydromyricetin to Take, and When

There's no established DHM dosage for people: human studies used 300 to 970 mg a day, while supplement labels range from about 100 mg to 3,250 mg per serving, so follow your label and ask a clinician first if you take medicines. The top of that range is our own product, After Party by Fuller Health, and its 3,250 mg serving is higher than any dose in published human DHM studies; safety at that dose hasn't been studied.

Key takeaways

  • Published human DHM trials used 300 to 970 mg a day, in adults with fatty liver disease or type 2 diabetes, for 1 to 12 months; none involved alcohol.1, 2, 3
  • NIH's LiverTox lists a typical DHM dose of 300 to 1,000 mg a day.4
  • In a 2021 survey of 82 hangover products, 59% of those containing DHM didn't state how much DHM they contained.5
  • As of October 2026, no human study has tested when to take DHM, or whether a higher dose does more.6
  • After Party's label directions (3 capsules before bed, 2 upon waking) add up to 3,250 mg of DHM, about 3.4 times the highest daily dose with published human data.2

Why is there no proven DHM dosage?

Because the studies that would define one haven't been done. Setting a dose means testing several amounts in people and measuring absorption, effects and side effects.

  • No trial for hangover. As of October 2026, no randomized trial of DHM alone for hangover had been published in a PubMed-indexed journal.6
  • No human absorption data. Nobody knows how much DHM reaches the blood at any dose.7
  • No dose comparisons. No human study has compared one DHM dose with another.
  • Animal doses don't translate. The famous 2012 rat study injected 1 mg/kg into the abdomen; a 2020 rat study gave 10 mg/kg by mouth.8, 9 In mice, the same dose produced up to 24 times less blood exposure by mouth than by injection.10
  • The human trials answered other questions. They used 300 to 970 mg a day to study lab markers in people with fatty liver disease or diabetes, not drinking.1, 2, 3

What doses were used in research vs. on labels?

Research doses top out at 970 mg a day. Labels go much higher.

DHM amounts in research and on labels, as of October 2026
Source DHM amount Who or what Notes
Chen et al. 20151 300 or 600 mg a day 60 adults with fatty liver disease, 3 months The abstract's dosing wording can be read either way.
Ran et al. 20192 970 mg a day 80 adults with type 2 diabetes, 1 month Given in 10 g of vine tea a day.
Michailidou et al. 20263 300 mg a day 55 adults with fatty liver disease, 12 months Combined with vitamins C and E and choline.
Phase 1 absorption study (registered)7 300 mg or 900 mg, with or without lysine 12 healthy volunteers Last listed as not yet recruiting; no results posted.
NIH LiverTox4 300 to 1,000 mg a day Described as the "typical" dose A description, not a recommendation.
DHM labels we checked, October 9, 2026 About 100 mg to 3,250 mg per serving US supplements Some products don't disclose DHM at all.
After Party (label) 3,250 mg per 5-capsule serving Fuller Health's product Above every published human dose. Not studied at this amount.

More isn't shown to be better: no one has compared DHM doses in people, so a bigger number on a label is a fact, not a benefit.

How do DHM serving sizes compare, per serving and per capsule?

Compare both, because serving sizes differ. Among the DHM labels we checked on October 9, 2026, servings ranged from 1 to 5 capsules or tablets, and DHM ranged from about 50 mg to 1,000 mg per capsule or tablet.

Per capsule tells you how many pills you'll swallow; per serving tells you how much DHM you take at the label dose. Neither tells you whether it works. After Party, for example, has 650 mg per capsule and 5 capsules per serving.

When should you take DHM: before bed, during drinking or the next morning?

Nobody knows, because no human study has tested DHM timing. Any timing advice, including on labels, is a judgment call rather than a researched protocol.

The only timing data come from rodents. In rats, blood DHM peaked about 2.7 hours after an oral dose and had a half-life of about 3.7 hours.11 In mice the oral half-life was under 2 hours, and injected DHM's anti-intoxication effect was short-lived.6, 10 Those numbers can't simply be applied to people.

What we'd avoid: taking extra doses while drinking, stacking several DHM products, or treating any timing as a reason to drink more or to drive. And be wary of labels or ads that tie timing to preventing a hangover; FDA's 2020 warning letters treated claims to prevent hangovers as drug claims.12

How do you read a DHM label? Extract weight vs. actual DHM

Look for the milligrams of DHM itself, not just the weight of an extract.

  • Check the serving size (how many capsules) next to the amount per serving on the Supplement Facts panel.
  • Do the math on standardized extracts. 500 mg of extract standardized to 98% DHM is 490 mg of DHM; at 50%, it's 250 mg.
  • Don't count Hovenia extract as DHM. Analyzed Hovenia extracts are less than 1% DHM, so 1,000 mg may hold under 10 mg.6
  • Watch for proprietary blends, which list one total weight for several ingredients, so you can't tell how much DHM is inside.
  • Look for a test report. A certificate of analysis that reports DHM per serving lets you check the label. After Party's published certificate for lot 1032 (manufactured June 2023) reports 3,250 mg of DHM per serving.13

Our full guide is how to read a supplement label.

Should you take DHM with food and water?

There are no data either way: no study has compared DHM taken with or without food in people. Take capsules as your label directs. If you're drinking, eating slows how fast alcohol is absorbed, which is worth doing for its own sake.14

Who should check with a clinician first?

  • Anyone taking prescription medicines. In test-tube studies with human liver enzymes, DHM inhibited CYP3A4, CYP2D6 and CYP2E1, enzymes that help clear many medications.15 That hasn't been tested in people, so ask a pharmacist or doctor first if you take prescription medicines.
  • Anyone taking sedatives, sleep medicines or anti-anxiety drugs. In rodents DHM acts at the benzodiazepine site of GABA-A receptors; combinations haven't been studied in people.8
  • People with liver or kidney disease, and older adults. DHM hasn't been studied in these groups at high doses.
  • Anyone pregnant or breastfeeding. DHM hasn't been studied in pregnancy or breastfeeding. Don't use it.
  • Anyone under 21. DHM products marketed around drinking are for adults only.

For the full picture, see Is DHM safe? and can you take DHM every day?

How do After Party's directions work? 3 before bed, 2 upon waking

After Party's label says to take 3 capsules before bed and 2 capsules upon waking. That's one 5-capsule serving: 1,950 mg of DHM at bedtime and 1,300 mg on waking, 3,250 mg in all.

After Party by Fuller Health is a single-ingredient DHM supplement: 650 mg of dihydromyricetin per capsule, 3,250 mg per 5-capsule serving, with nothing else but the cellulose capsule. (Fuller Health publishes this page and makes After Party.) A 50-capsule bottle holds 10 servings. Follow the label, and don't add doses while drinking.

No study has tested this split schedule, or any DHM schedule, in people. After Party's 3,250 mg serving is higher than the doses used in published human DHM studies. Those studies gave up to about 970 mg a day, to people with fatty liver disease or type 2 diabetes, not to people who drink.2, 1, 3 Safety at 3,250 mg hasn't been studied. After Party will not prevent intoxication, lower your blood alcohol, or make it safe to drive. For details, see how to take After Party and the After Party facts page.

What we don't know yet about DHM dosage

  • Whether any DHM dose has a meaningful effect in people who drink.
  • The safe upper limit, for a single serving or for repeated use.
  • The best timing, if timing matters at all.
  • How much DHM people absorb, how long it lasts, and whether food changes that.

Our DHM research tracker logs every key study, and what DHM is covers the basics.

Frequently asked questions

How much DHM should I take?

There's no proven amount. Human studies used 300 to 970 mg a day in people with fatty liver disease or diabetes, and NIH's LiverTox lists 300 to 1,000 mg a day as typical.4 Follow your label, and ask a pharmacist first if you take medicines. Some products, including After Party (3,250 mg per serving), exceed the studied range, and safety there hasn't been studied.

Should I take DHM before or after drinking?

No human study has tested DHM timing, so there's no evidence-based answer. Follow your label, don't add doses while drinking, and don't treat a supplement as a reason to drink more or to drive.

Can you take too much DHM?

No one has established an upper limit in people. The highest published human dose is 970 mg a day, for one month.2 Above that, safety is unknown, so don't exceed your label or combine DHM products.

How long does DHM stay in your system?

Unknown in people, because no human absorption study has been published.7 In rats, DHM taken by mouth had a half-life of about 3.7 hours, and in mice under 2 hours, but animal numbers don't translate directly to humans.11, 6

Should I take DHM with food?

There's no research on DHM with or without food in people, so take it as your label directs. If you're drinking, eating slows alcohol absorption.14

Sources

  1. Chen S, et al. Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial. Pharmacol Res. 2015;99:74-81. PubMed
  2. Ran L, et al. Ampelopsis grossedentata supplementation effectively ameliorates the glycemic control in patients with type 2 diabetes mellitus. Eur J Clin Nutr. 2019;73(5):776-782. PubMed
  3. Michailidou E, et al. Dietary supplement based on dihydromyricetin in metabolic dysfunction-associated steatotic liver disease: a double-blind, placebo-controlled, randomized clinical trial. Ann Gastroenterol. 2026;39(1):54-62. PubMed
  4. National Institute of Diabetes and Digestive and Kidney Diseases. LiverTox: Dihydromyricetin. NCBI Bookshelf. Last updated August 16, 2023. NCBI Bookshelf
  5. Verster JC, et al. Unknown safety and efficacy of alcohol hangover treatments puts consumers at risk. Addict Behav. 2021;122:107029. PubMed
  6. Skinner SG, et al. Therapeutic Effects of Dihydromyricetin on Wholly Alcohol-Attributed Conditions: A Systematic Review. Nutrients. 2026;18(14):2221. PubMed
  7. University of Southern California. Phase I, Dose-Escalation Study of Dihydromyricetin (DHM) to Treat Alcohol-Associated Liver Disease (NCT05623501). ClinicalTrials.gov. Status unknown; no results posted as of October 9, 2026. ClinicalTrials.gov
  8. Shen Y, et al. Dihydromyricetin as a novel anti-alcohol intoxication medication. J Neurosci. 2012;32(1):390-401. PubMed
  9. Skotnicová A, et al. Does dihydromyricetin impact on alcohol metabolism. Physiol Res. 2020;69(Suppl 4):S573-S581. PubMed
  10. Carry E, et al. Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice. Int J Mol Sci. 2021;22(14):7460. PubMed
  11. Liu L, et al. Determination of dihydromyricetin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Pharm Biol. 2017;55(1):657-662. PubMed
  12. U.S. Food and Drug Administration. FDA Sends Warning Letters to Seven Companies Illegally Selling Hangover Products. Constituent update, July 29, 2020. FDA
  13. Fuller Health. After Party certificate of analysis, lot 1032 (manufactured June 2023). Testing laboratory not named on the document. PDF
  14. Cederbaum AI. Alcohol metabolism. Clin Liver Dis. 2012;16(4):667-85. PubMed
  15. Liu L, et al. In vitro inhibitory effects of dihydromyricetin on human liver cytochrome P450 enzymes. Pharm Biol. 2017;55(1):1868-1874. PubMed
  16. U.S. Department of Agriculture; U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2025-2030. Released January 7, 2026. PDF
  17. National Institute on Alcohol Abuse and Alcoholism. Hangovers. Updated December 2025. NIAAA

Published by Fuller Health, which makes After Party. This article is general information, not medical advice: talk to a doctor or pharmacist about your own health, medicines and drinking. Last reviewed October 9, 2026. How we research and write.

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